Our church received several hundred thousand dollars. Our first step was to find the 105 families in our church whose homes were destroyed and give them a check for $1,000. That may sound like a lot, but it doesn't go very far if you are staying in a hotel or lost your apartment and everything in it and didn't have renter's insurance. Later our members in greatest need were given thousands of additional dollars to help them with house rebuilding or repair (many were grossly under-insured).
For the community, we set up Mission Joplin and gave away free clothing, household goods, furniture, appliances, etc. In the early days we had about 200 families a DAY coming through our facility and getting help, all funded by donations. Two years + later, all of the money that came in has gone to the people who needed it. We didn't use any donated funds for overhead, salaries, etc. It all went to those in need, either in the form of cash or goods. We feel really good about the thousands of families we've been able to help.
If you can find a church or not-for-profit organization doing that kind of work in Colorado, you can often get a charitable contribution credit. If you don't want or need that kind of credit for your income taxes, direct help is not a bad idea. We know who runs businesses in Estes Park and they are going to be hurting due to the lack of tourists. Some of them sell products we can buy online. Some of them would appreciate a check or gift card. Our experience was that some of the most needy families in our church were too proud to ask for help. But when we gave it, they often broke down in tears saying that they didn't know how they were going to make it and that our gift was an answer to prayer.
I'm not telling anyone what to do...follow your own heart on that. This is just my own experience for what it's worth. The need right now isn't for used clothing. A lot of families are going to need some cash to tide them over until they can get back to their property and start the process of rebuilding or relocating.